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KMID : 0363620050260040046
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Journal of Korean Oriental Medicine
2005 Volume.26 No. 4 p.46 ~ p.55
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Effects of Ampelopsis Radix Extracts on Tumor Immunity
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Park SM
Cho JH/Son CG/Shin JW/Lee YW/Yoo HS/Lee NH/Yun DH/Ahn SW/Cho CK
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Abstract
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Objectives: This experimental study was carried out to evaluate the immune modulating and anti-tumor activity of Ampelopsis Radix extracts (ARE). Materials and
Methods: To elucidate the effects of ARE on the macrophage and NK cell activity, we analyzed NO production, NK cytotoxicity and gene expressions of cytokine related with macrophage and NK cell activity.
Results: ARE activated and promoted macrophages to product NO in part. And, ARE has significant properties to activate macrophages and NK cells by promoting related cytokines like IL-1, IL-12, IFN-gamma, iNOS and TNF-alpha gene expressions. We also observed that ARE promoted protein expression of IFN-gamma, and TNF-alpha in mice splenocytes.
Conclusions: ARE is an effective herbal drug for immune modulating and anti-cancer by promoting activity of macrophages and NK cells.
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KEYWORD
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